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Título : Immunology of Human Gastric Cancer: A Preliminary Report
Autor : BLANCA, ISAAC
GRASES, PEORO J.
MATOS V, MARCOS
CONTRERAS, CARMEN E.
OCHOA, MARIANGEL
WRIGHT, HARLAM
Bianco Colmenares, Nicolás E.
Palabras clave : immunological spectrum
gastric cancer
nonadvanced cancer
tumors
circulating immune complexes
hyporesponsiveness
phytohemagglutinin
lymphocyte culture
Fecha de publicación : 1-May-1982
Editorial : the American Cancer Society, lnc.
Citación : Vol. 49;No. 9
Resumen : The immunological spectrum in fifteen patients with gastric cancer is presented. Patients were divided in three groups. Those with nonadvanced cancer, those with advanced but resectable lesions and those with advanced but nonresectable tumors. Preoperatively, elevated levels of circulating immune complexes (CIC) associated with hyporesponsiveness to phytohemagglutinin (PHA) and in mixed lymphocyte culture (MLC) as well as a positive leukocyte inhibitory serum factor (LIF-S) were found in nearly half of the patients. Inhibitory or enhancing autologous serum factors were detected. Postoperatively, immunologic parameters return to normal in patients with nonadvanced cancer, while in advanced cancer, antibody and cell-mediated immune response remained altered, with some changes associated with chemotherapy. These findings are probably related with the presence or absence of tumor and offer a distinct approach in evaluating the immunologic response of a tumor-bearing patient, Cancer 49:1810-1816, 1982.
URI : http://hdl.handle.net/123456789/14053
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