SABER UCV >
1) Investigación >
Artículos Publicados >

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/123456789/13208

Título : LEUKOCYTE SUBSETS IN THE GRANULOMATOUS RESPONSE PRODUCED AFTER INOCULATION WITH MYCOBACTERIUM LEPR 4E BCG IN LEPROMATOUS PATIENTS
Autor : Gross, Ana
Weiss, Eduardo
Tapia, Félix J.
Aranzazu, Nacarid
Gallinoto, María E.
Convit, Jacinto
Palabras clave : Leukocyte subsets
granulomatous
Mycobacterium leprae
lepromatous leprosy patients
monoclonal antibodies
immunoperoxidase technique
Fecha de publicación : 1988
Editorial : The American Journal of Tropical Medicine and Hygiene
Citación : Vol. 38;Nº 3
Resumen : Leukocyte subsets present in the granulomatous response produced after the inoculation of a mixture of Mycobacterium leprae and BCG in lepromatous leprosy patients Were Characterized in situ using monoclonal antibodies and an immunoperoxidase technique. The granuloma produced after M. leprae -BCG Showed a distribution like pattern to tuberculoid granulomas . T lymphocytes bearing the CD8 phenotype (T cytotoxic / suppressor) Were sequestered to the periphery of the epithelioid tubercles and T helper-inducer CD4 + lymphocytes infiltrate the Were distributed THROUGHOUT. Langerhans cells CD1 + Were Increased in the epidermis, dermis and in They Were localized mainly in the mantle surrounding the granuloma . Most of the dermal infiltrate produced after the inoculation or M. leprae -BCG expresses the HLA antigen -DR. Similarly, keratinocytes Were MOST Also positive to this MHC antigen. The granulomatous response to BCG was similar to the inoculation of a mixture of M. leprae -BCG, however acid-fast bacilla Were still present. The inoculation of M. leprae produced by macrophage granuloma With No clearing of the bacilla Which Resembles the lepromatous leprosy granuloma.
URI : http://saber.ucv.ve/jspui/handle/123456789/13208
ISSN : 0002-9637
Aparece en las colecciones: Artículos Publicados

Ficheros en este ítem:

Fichero Descripción Tamaño Formato
Gross et al 1988 lepra.pdf216.27 kBAdobe PDFVisualizar/Abrir

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2008 MIT and Hewlett-Packard - Comentarios