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|Título : ||Nitric oxide in different types of hypertension during pregnancy|
|Autor : ||Garmendia, Jenny V.|
Bianco Colmenares, Nicolás E.
De Sanctis, Juan B.
|Palabras clave : ||Nitric oxide|
|Fecha de publicación : ||1997|
|Editorial : ||Clinical Science|
|Citación : ||Vol. 93; Nº 5 pp 413-421.|
|Resumen : ||1. Serum nitric oxide (NO) levels (determined by
its products of oxidation) were assessed in nonpregnant
women, normal pregnant women and
patients suffering from mild pre-eclampsia (MPE),
severe pre-eclampsia (SPE), chronic hypertension
(CHT) and CHT with pre-eclampsia (CHT+PE).
The levels of NO products were significantly
reduced during pregnancy in MPE (P < 0.001),
CHT+PE (P < 0.01) and SPE (P < 0.05). Significant
reductions of NO products were also observed in
puerperium (P < 0.001) in all groups except
2. In normal pregnancy, three events were related to
NO levels: (1) negative correlations were found
between the levels of nitrite (r = -0.73, P = 0.0003),
nitrate (r = -0.53, P = 0.017) and the number of
weeks of gestation; (2) in the caesarean section
group, the levels of NO at puerperium were significantly
lower (P < 0.05) than those during pregnancy;
and (3) there was a significant reduction in NO
levels in the pregnant women carrying male fetuses
as compared with female fetuses (Px0.05).
3. In SPE, the patients with a family history of
hypertension had lower levels of NO compared with
the patients without such a history (P<0.05).
4. A negative correlation was observed between systolic
blood pressure, diastolic blood pressure and
NO levels in MPE (r = -0.62, P = 0.013 and
r = -0.68, P = 0.0049 respectively) and SPE
(r = -0.72, P = 0.004 and r = -0.53, P = 0.037
5. In SPE, positive correlations were observed
between platelet count and nitrite (r = 0.67, P=
0.006) and nitrate levels (r = 0.56, P = 0.028).
6. In MPE, patients with anti-hypertensive treatment
showed significantly (P < 0.05) higher levels of
NO compared with the non-treated patients.
7. NO may be important in the physiopathology of
hypertension during pregnancy, although several
factors may affect its levels.|
|URI : ||http://saber.ucv.ve/jspui/handle/123456789/12108|
|ISSN : ||1470-8736|
|Aparece en las colecciones: ||Artículos Publicados|
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