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Título : IMMUNOPATHOLOGY OF HUMAN SCHISTOSOMIASIS MANSONI. II. NK ACTIVITY AND STIMULATION BY SPECIFIC ANTIGEN
Autor : BENARROCH, O.
NOYA, O.
NOYA, B.
BLANCA, I.
Bianco Colmenares, Nicolás E.
Palabras clave : Natural Killer cells
S. mansoni
Fecha de publicación : 1988
Editorial : Rev. Inst. Med. trop. Sao Paulo
Citación : vOL. 30;6
Resumen : Sixteen S. mansoni infected and untreated patients (5 with recent infection and 11 with chronic disease) were evaluated for their in v i t r o natural killer ( N K ) activity against the N K sensitive target K562 cell line. N K levels in 9 out of 11 patients (82%) w i th chronic disease were significantly lower (mean = 15 ± 6%), compared with patients recently infected (mean = 41 ± 9% p < 0.001) and with the control group (mean = 38 ± 13% p < 0.001). However, both patients and controls N K activity was stimulated by soluble adult worm antigens (SAWA) , indicating that N K function even in the chronic stage of the infection is able to respond to the parasite antigens. Thes e results suggest the possibility of N K cell participati on as effector mechanism against S . mansoni.
URI : http://saber.ucv.ve/jspui/handle/123456789/12074
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