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Título : Variations in the serum levels of soluble CD23, nitric oxide and IgE across the spectrum of American cutaneous leishmaniasis
Autor : Cabrera, Maira
Rodríguez, Orquídea
Monsalve, Iraima
Tovar, Robert
Hagel, Isabel
Palabras clave : cutaneous leishmaniasis
Nitric Oxide
Fecha de publicación : Oct-2003
Editorial : Elsevier
Citación : Acta Tropica 88 (2003) 145–151
Citación : 88;
Resumen : Serum IgE levels and the expression of low affinity receptor for IgE (FcεRII/CD23) are increased in cutaneous leishmaniasis. The ligation of CD23 receptor by IgE–anti-IgE immune complexes results in nitric oxide (NO) production, which is a critical leishmanicidal factor. Human monocytes/macrophages express FcεRII/CD23 after activation with IFN- and IL-4. In the present study,we assessed the relationship between NO, total and Leishmania-specific IgE and soluble CD23 across the clinical spectrum of American cutaneous leishmaniasis (ACL). Sixty-nine ACL patients and 22 endemic controls were studied. NO concentration was estimated using the Greiss method. Soluble CD23, total IgE and anti-Leishmania IgE levels were measured using ELISA. Soluble CD23 was increased in the four patient groups (0.001 < P < 0.05) compared by the Mann–Whitney test to healthy subjects, particularly in mucocutaneous leishmaniasis (MCL) and diffuse cutaneous leishmaniasis (DCL) patients. Total IgE levels were higher inACL patients (P < 0.0001). Anti-Leishmania IgE showed a similar tendency, whereMCLand DCL patients had greater levels. All patients groups, except intermediate or chronic cutaneous leishmaniasis (ICL) patients, showed elevated levels of NO2−/NO3 − compared to healthy individuals (0.001 < P < 0.01). Interestingly, ICL patients did not produce significant levels of NO2−/NO3−. ACL patients showed a significant positive correlation between soluble CD23 and anti-Leishmania IgE. DCL patients showed a positive correlation between both parameters. Overall results suggest that sCD23, IgE and NO may play different roles across the ACL spectrum.
ISSN : 0001-706X
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