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http://hdl.handle.net/10872/1697
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| Título : | Antitrypanosomal Activity of Quaternary Naphthalimide Derivatives |
| Autor : | Muth, Mathias
Hoerr, Verena
Glaser, Melanie
Ponte-Sucre, Alicia
Moll, Heidrun
Stich, August
Holzgrabe, Ulrike |
| Palabras clave : | Sleeping sickness
Trypanosoma brucei
quaternary and tertiary naphthalimides |
| Fecha de publicación : | 23-Aug-2012 |
| Citación : | Bioorganic Medicinal Chemistry Letters;17: 1590-1593, 2007 |
| Resumen : | Sleeping sickness caused by Trypanosoma brucei gambiense and rhodesiense is fatal if left untreated. Due to the toxicity of
drugs currently used and the emerging resistance against these drugs new lead compounds are urgently needed. Within the frame of
a broad screening program for drugs with antitrypanosomal activity, some highly potent tertiary and quaternary mono- and bisnaphthalimides
being active in the lower micromolar and nanomolar range of concentration have been identified. These compounds
are easily available via a two- or three-step microwave-driven synthesis with high yield. |
| URI : | http://hdl.handle.net/10872/1697 |
| ISSN : | 0960-894X |
| Aparece en las colecciones: | Artículos Publicados
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