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Título : Differential expression of antimicrobial peptides in active and latent tuberculosis and its relationship with diabetes mellitus
Autor : Gonzalez- Curiel, Irma
Castañeda- Delgado, Julio
Lopez-Lopez, Nallely
Araujo, Zaida
Hernandez- Pando, Rogelio
Gandara- Jasso, Benjamin
Macias- Segura, Noe
Enciso-Moreno, Antonio
Rivas- Santiago, Bruno
Palabras clave : Tuberculosis
Antimicrobial peptides
Fecha de publicación : 2011
Editorial : Human Immunology
Citación : Vol. 72;8
Resumen : Tuberculosis (TB) is one of the most important infectious diseases, causing 1.8 million deaths annually worldwide. This problem has increased because of the association with human immmunodeficiency virus and diabetes mellitus type 2, mainly in developing countries. In the past few years it has been highlighted the significance of antimicrobial peptides in the immunopathogenesis of TB ex vivo and in experimental models studies. In this study we analyzed the expression of CAMP, DEFA1, DEFB4, and DEFB103A in patients with latent TB and progressive TB with and without comorbidity with diabetes mellitus type 2. Antimicrobial peptide gene expression increased during progressive TB, which could be used as a biomarker for reactivation. By contrast, patients with diabetes mellitus type 2 have lower antimicrobial peptides gene expression, suggesting that the lack of its proper production in these patients contribute to enhance the risk for TB reactivation.
ISSN : 0198-8859
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